
The Axoporator 800 A electroporator, the world's first commercially available single-cell electroporator, represents the convergrence of biophysics, cell biology and molecular biology. This micropipette-based delivery system uses voltage pulses to cause the transient formation of membrane pores through which flow impermeant molecules and/or ions. The mechanism is the same as that used for the bulk electroporation of suspended cells dielectric breakdown of the membrane by a voltage pulse however, single-cell electroporation offers distinct advantages over bulk electroporation.